Scientists explain the rare hyper-inflammatory syndrome in COVID-19 infected children



(Image courtesy: Consiglio et al.,Cell, DOI: 10.1016/j.cell.2020.09.016; 2020)


During the COVID-19 pandemic, pediatricians have discovered a new, life-threatening hyper-inflammatory syndrome resembling Kawasaki disease and named it Multisystem Inflammatory Syndrome in Children (MIS-C). Scientists of Karolinska Institute and Science and for Life Laboratory in Sweden and Tor Vergata University of Rome in Italy have formulized the immunological aspects of this rare condition. The researchers claim that the hyperinflammation and cytokine storm detected in children with MIS-C is different from that observed in adults. The common cold coronavirus related IgG antibodies are not found in the body of children who developed MIS-C with COVID-19. Several antibodies which attack the body’s own proteins were also detected in these children. The researchers are also looking for genetic risk factors for developing MIS-C after COVID-19 infection. The details of the study are published in Cell after peer review.


Source: Cell, DOI: 10.1016/j.cell.2020.09.016; 2020