Phytochemicals as potential therapeutic agents against COVID-19 infection


Phytochemicals are potential molecules that are finding applications in drug industry. Researchers at the Guru Govind Singh Indraprastha University, Delhi have computationally analyzed several phytochemical compounds and found a few that are able to bind with the non-structural protein 15 (Nsp 15) which is known to play a critical role in virulence of SARS-CoVs. These compounds are sarsasapogenin, ursonic acid, curcumin, ajmalicine, novobiocin, silymarin and aranotin, piperine, gingerol, rosmarinic acid, and alpha terpinyl acetate. These results indicate the need for in vivo and in vitro tests for further confirmation of the study. The details of the research have been published in the journal Phytomedicine after peer review.


Source: Phytomedicine; DOI: 10.1016/j.phymed.2020.153317; 2020